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A companion core from the same cluster was used for the gene profiling and validation studies reported here

HUBERMAN: Those are just two examples of peptides that are familiar to most people, at least by name, and that exist within the tens of thousands, if not hundreds of thousands of different peptides that exist within our brain and body

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Notably, results were consistent after excluding from the main analysis tirzepatide, the only agent with a dual action on GIP and GLP-1 receptors

As a consequence, lower cut-off points in these patient groups may be appropriate